Microfluidic Applications in Vascular Bioengineering
نویسندگان
چکیده
Blood, the vascular tissue, is vital for nutrient transport, immune-surveillance, hemostasis, and wound healing, all of which are critical in order to maintain normal physiology (Lichtman, et al., 2006; Rosenberg & Aird, 1999). Consequently, the pathophysiology of a large number of diseases can be traced to abnormalities in blood flow and function. Hence, assays for composition and function of blood are crucial in both diagnosis and treatment of diseases (Barone & Feuerstein, 1999; Danesh, Collins, Appleby, & Peto, 1998; VanWijk, VanBavel, Sturk, & Nieuwland, 2003). Blood is a complex tissue comprised of both cellular and acellular components. The cellular components are composed of erythrocytes, leukocytes, and platelets, and the acellular components ABSTRACT
منابع مشابه
Vasculature-On-A-Chip for In Vitro Disease Models
Vascularization, the formation of new blood vessels, is an essential biological process. As the vasculature is involved in various fundamental physiological phenomena and closely related to several human diseases, it is imperative that substantial research is conducted on characterizing the vasculature and its related diseases. A significant evolution has been made to describe the vascularizati...
متن کاملValidation of a fully integrated platform and disposable microfluidic chips enabling parallel purification of genome segments for assembly.
Recent progress in the field of genetic engineering has opened up the door to novel synthetic biology applications. Microfluidic technology has been emphasized as a key technology to support the development of these applications. While several important synthetic biology protocols have been developed in microfluidic format, no study has yet demonstrated on-chip error control. In synthetic biolo...
متن کاملDrug Discovery Acceleration Using Digital Microfluidic Biochip Architecture and Computer-aided-design Flow
A Digital Microfluidic Biochip (DMFB) offers a promising platform for medical diagnostics, DNA sequencing, Polymerase Chain Reaction (PCR), and drug discovery and development. Conventional Drug discovery procedures require timely and costly manned experiments with a high degree of human errors with no guarantee of success. On the other hand, DMFB can be a great solution for miniaturization, int...
متن کاملSilica-immobilized enzymes for multi-step synthesis in microfluidic devices.
The combinatorial synthesis of 2-aminophenoxazin-3-one (APO) in a microfluidic device is reported. Individual microfluidic chips containing metallic zinc, silica-immobilized hydroxylaminobenzene mutase and silica-immobilized soybean peroxidase are connected in series to create a chemo-enzymatic system for synthesis. Zinc catalyzes the initial reduction of nitrobenzene to hydroxylaminobenzene wh...
متن کامل3D-printed microfluidic chips with patterned, cell-laden hydrogel constructs.
Three-dimensional (3D) printing offers potential to fabricate high-throughput and low-cost fabrication of microfluidic devices as a promising alternative to traditional techniques which enables efficient design iterations in the development stage. In this study, we demonstrate a single-step fabrication of a 3D transparent microfluidic chip using two alternative techniques: a stereolithography-b...
متن کامل